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Search Results for " mitogen-activated protein kinase kinase 6 "

Targets Recommended: p38 MAPK Serine Protease MAPK

6

抑制剂 & 化合物

4

天然产物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16501	PF-3644022	p38 MAPK; Serine Protease; MAPK	MAPK; Proteases/Proteasome
	PF-3644022 是可口服的，具有 ATP 竞争性的MAPKAPK2 (MK2)选择性抑制剂，IC50为 5.2 nM，Ki 为 3 nM。它有效抑制 TNFα 的产生并具有抗炎作用，还抑制 MK3 和 p38 调节/激活激酶，IC50分别为 53 和 5.0 nM。
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T37739	N-decanoyl-L-Homoserine lactone C10-HSL,N-decanoyl-L-Homoserine lactone	Reactive Oxygen Species; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	N-decanoyl-L-Homoserine lactone (C10-HSL) 是一种由克雷莫里色假单胞菌菌株 ND07产生的 N-acyl-homoserine lactone (AHL)。N-decanoyl-L-homoserine lactone 可抑制拟南芥的主根生长。N-decanoyl-L-homoserine lactone 处理可引起拟南芥根胞质游离 Ca2+ 和活性氧 (ROS) 浓度短暂和和立即升高，增加丝裂原激活蛋白激酶 6 (MPK6) 的活性，并促使一氧化氮 (NO) 的产生。
T76242	MMI-0100
	MMI-0100 是一种细胞渗透性肽抑制剂，抑制丝裂原活化蛋白激酶活化蛋白激酶 II (MK2)。MMI-0100 在体内外减少内膜增生。MMI-0100 抑制IL-6表达而不影响IL-8表达。MMI-0100 抑制纤维化过程，例如静脉移植疾病。
T69451	R-130823
	R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated ...
T35593	Semapimod tetrahydrochloride CPSI-2364 tetrahydrochloride	TLR; MAPK	Immunology/Inflammation; MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) 是一种合成鸟腙丝裂原活化蛋白激酶阻滞剂,也是促炎细胞因子生成抑制剂，干扰巨噬细胞和小胶质细胞功能。Semapimod tetrahydrochloride 可抑制 TLR4 信号传导，抑制 TNF-α、IL-1β 和 IL-6，可用于研究克罗恩病和其他炎症。

化合物

Cat.No: T16501

Target: p38 MAPK, Serine Protease, MAPK

Cat.No: T12781

Target: Others

N-decanoyl-L-Homoserine lactone

Cat.No: T37739

Synonym: C10-HSL,N-decanoyl-L-Homoserine lactone

Target: Reactive Oxygen Species, Antibacterial

Cat.No: T76242

Cat.No: T69451

Semapimod tetrahydrochloride

Cat.No: T35593

Synonym: CPSI-2364 tetrahydrochloride

Target: TLR, MAPK

Cat. No.	Product Name	Target	Signaling Pathways
T3816	Velutin	NF-κB; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; NF-κB
	Velutin 是一种苷元，提取自槲寄生中，能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。
TN1410	Asperulosidic acid ASPA,车叶草苷酸	ERK; NF-κB	MAPK; NF-κB
	Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷，具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。

天然产物

Cat.No: T3816

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

Asperulosidic acid

Cat.No: TN1410

Synonym: ASPA,车叶草苷酸

Target: ERK, NF-κB

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04749	MKK6 Protein, Human, Recombinant (S207D, T211D) MAPKK6,PRKMK6,MKK6,MEK6,...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (S207D, T211D) is expressed in Baculovirus insect cells. The predicted molecular weight is 37.7 kDa and the accession number is P52564-1.
TMPY-04365	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) SAPKK3,mitogen-activated protein ...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1.
TMPY-04748	MKK6 Protein, Human, Recombinant MKK6,MAPKK6,SAPKK-3,SAPKK3,PRKMK6...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 37.6 kDa and the accession number is A8K3Y2.
TMPY-04364	MKK6 Protein, Human, Recombinant (His & GST) MKK6,mitogen-activated protei...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1.
TMPY-04430	p38 gamma/MAPK12 Protein, Human, Recombinant mitogen-activated protein	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
TMPY-04429	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) ERK3,SAPK3,PRKM12,ERK6,P38γ,P38GAMMA,mitogen	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP) MKP6,MKP-L,dual specificity phosphatase 14	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (...
TMPJ-00567	NCR1 Protein, Human, Recombinant (hFc) hNKp46,Natural cytotoxicity triggering receptor 1,N...	Human	HEK293 Cells
	Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Microtubule-A...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPY-03128	LAIR1 Protein, Mouse, Recombinant (hFc) leukocyte-associated immunoglobulin-like receptor 1,BB1152	Mouse	HEK293 Cells
	LAIR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is Q8BG84-6.
TMPY-02705	NRG1 beta 1 Protein, Human, Recombinant (hFc) MSTP131,HRG1,NRG1-IT2,ARIA,HGL,SMDF,GGF,HRG,NDF,MST131,neure...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
TMPK-00614	NKp46/NCR1 Protein, Human, Recombinant (His) NKp46,MAR-1,Ly94,NCR1,NKP46FLJ99094,CD335	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession numb...
TMPY-03010	NRG1 beta 1 Protein, Human, Recombinant NDF,GGF,MSTP131,Neuregulin 1,MST131,ARIA,NRG1-IT2,SMDF,NRG1 ...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
TMPK-00615	NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated CD335,NCR1,NKp46,NKP46FLJ99094,Ly94,MAR-1	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular we...
TMPY-04277	CD45 Protein, Mouse, Recombinant (hFc) Cd45,protein tyrosine phosphatase, receptor type, C...	Mouse	HEK293 Cells
	CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6.
TMPY-02600	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) neuregulin 1,HRGA,NRG1 β1,HGL,MST131,MSTP131,HRG,ARIA,NDF,GG...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.
TMPY-05798	VEGF145 Protein, Human, Recombinant 血管内皮生长因子,vascular endothelial growth factor A,VPF,MVCD1,VEGF...	Human	HEK293 Cells
	VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
TMPK-01358	SIRP alpha V6 Protein, Human, Recombinant (His & Avi) P84,SIRPA,SIRP alpha,SHPS-1,MFR,BIT,MYD1,SIRP α V6,...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...
TMPK-01364	SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

MKK6 Protein, Human, Recombinant (S207D, T211D)

Cat.No: TMPY-04749

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST)

Cat.No: TMPY-04365

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant

Cat.No: TMPY-04748

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04364

Species: Human

Expression System: Baculovirus Insect Cells

p38 gamma/MAPK12 Protein, Human, Recombinant

Cat.No: TMPY-04430

Species: Human

Expression System: Baculovirus Insect Cells

p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04429

Species: Human

Expression System: Baculovirus Insect Cells

DUSP14 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02595

Species: Human

Expression System: E. coli

NCR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00567

Species: Human

Expression System: HEK293 Cells

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

LAIR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03128

Species: Mouse

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02705

Species: Human

Expression System: HEK293 Cells

NKp46/NCR1 Protein, Human, Recombinant (His)

Cat.No: TMPK-00614

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant

Cat.No: TMPY-03010

Species: Human

Expression System: HEK293 Cells

NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00615

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04277

Species: Mouse

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)

Cat.No: TMPY-02600

Species: Human

Expression System: HEK293 Cells

VEGF145 Protein, Human, Recombinant

Cat.No: TMPY-05798

Species: Human

Expression System: HEK293 Cells

SIRP alpha V6 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01358

Species: Human

Expression System: HEK293 Cells

SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01364

Species: Human

Expression System: HEK293 Cells

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